Differential functional effects of novel mutations of the transcription factor FOXL2 in BPES patients
Identifieur interne : 000434 ( France/Analysis ); précédent : 000433; suivant : 000435Differential functional effects of novel mutations of the transcription factor FOXL2 in BPES patients
Auteurs : Jeyabalan Nallathambi [Inde] ; Paul Laissue [France] ; Frank Batista [France] ; Bérénice A. Benayoun [France] ; Corinne Lesaffre [France] ; Lara Moumné [France] ; Pj Eswari Pandaranayaka [Inde] ; Kim Usha [Inde] ; Sankaran Krishnaswamy [Inde] ; Periasamy Sundaresan [Inde] ; Reiner A. Veitia [France]Source :
- Human Mutation [ 1059-7794 ] ; 2008-08.
Abstract
Mutations of the transcription factor FOXL2, involved in cranio‐facial and ovarian development lead to the Blepharophimosis‐Ptosis‐Epicanthus Inversus Syndrome (BPES) in human. Here, we describe nine mutations in the open reading frame of FOXL2. Six of them are novel: c.292T>A (p.Trp98Arg), c.323T>C (p.Leu108Pro), c.650C>G (p.Ser217Cys) and three frameshifts. We have performed localization and functional studies for three of them. We have observed a strong cytoplasmic mislocalization induced by the missense mutation p.Leu108Pro located in the forkhead (FKH) domain of FOXL2. In line with this, transcriptional activity assays confirmed the loss‐of‐function induced by this variant. Interestingly, the novel mutation p.Ser217Cys, mapping between the FKH and the polyalanine domain of FOXL2 and producing a mild eyelid phenotype, led to normal localization and transactivation. We have also modeled the structure of the FKH domain to explore the potential structural impact of the mutations reported here and other previously reported ones. This analysis shows that mutants can be sorted into two classes: those that potentially alter protein‐protein interactions and those that might disrupt the interactions with DNA. Our findings reveal new insights into the molecular effects of FOXL2 mutations, especially those affecting the FKH binding domain. © 2008 Wiley‐Liss, Inc.
Url:
DOI: 10.1002/humu.20809
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000929
- to stream Istex, to step Curation: 000929
- to stream Istex, to step Checkpoint: 001132
- to stream Main, to step Merge: 006F82
- to stream Main, to step Curation: 006E73
- to stream Main, to step Exploration: 006E73
- to stream France, to step Extraction: 000434
Links to Exploration step
ISTEX:13CCA258DAFD6CE074F7EB9382B0FED0A269F94ELe document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Differential functional effects of novel mutations of the transcription factor FOXL2 in BPES patients</title><author><name sortKey="Nallathambi, Jeyabalan" sort="Nallathambi, Jeyabalan" uniqKey="Nallathambi J" first="Jeyabalan" last="Nallathambi">Jeyabalan Nallathambi</name></author><author><name sortKey="Laissue, Paul" sort="Laissue, Paul" uniqKey="Laissue P" first="Paul" last="Laissue">Paul Laissue</name></author><author><name sortKey="Batista, Frank" sort="Batista, Frank" uniqKey="Batista F" first="Frank" last="Batista">Frank Batista</name></author><author><name sortKey="Benayoun, Berenice A" sort="Benayoun, Berenice A" uniqKey="Benayoun B" first="Bérénice A." last="Benayoun">Bérénice A. Benayoun</name></author><author><name sortKey="Lesaffre, Corinne" sort="Lesaffre, Corinne" uniqKey="Lesaffre C" first="Corinne" last="Lesaffre">Corinne Lesaffre</name></author><author><name sortKey="Moumne, Lara" sort="Moumne, Lara" uniqKey="Moumne L" first="Lara" last="Moumné">Lara Moumné</name></author><author><name sortKey="Pandaranayaka, Pj Eswari" sort="Pandaranayaka, Pj Eswari" uniqKey="Pandaranayaka P" first="Pj Eswari" last="Pandaranayaka">Pj Eswari Pandaranayaka</name></author><author><name sortKey="Usha, Kim" sort="Usha, Kim" uniqKey="Usha K" first="Kim" last="Usha">Kim Usha</name></author><author><name sortKey="Krishnaswamy, Sankaran" sort="Krishnaswamy, Sankaran" uniqKey="Krishnaswamy S" first="Sankaran" last="Krishnaswamy">Sankaran Krishnaswamy</name></author><author><name sortKey="Sundaresan, Periasamy" sort="Sundaresan, Periasamy" uniqKey="Sundaresan P" first="Periasamy" last="Sundaresan">Periasamy Sundaresan</name></author><author><name sortKey="Veitia, Reiner A" sort="Veitia, Reiner A" uniqKey="Veitia R" first="Reiner A." last="Veitia">Reiner A. Veitia</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:13CCA258DAFD6CE074F7EB9382B0FED0A269F94E</idno><date when="2008" year="2008">2008</date><idno type="doi">10.1002/humu.20809</idno><idno type="url">https://api.istex.fr/document/13CCA258DAFD6CE074F7EB9382B0FED0A269F94E/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000929</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000929</idno><idno type="wicri:Area/Istex/Curation">000929</idno><idno type="wicri:Area/Istex/Checkpoint">001132</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">001132</idno><idno type="wicri:doubleKey">1059-7794:2008:Nallathambi J:differential:functional:effects</idno><idno type="wicri:Area/Main/Merge">006F82</idno><idno type="wicri:Area/Main/Curation">006E73</idno><idno type="wicri:Area/Main/Exploration">006E73</idno><idno type="wicri:Area/France/Extraction">000434</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Differential functional effects of novel mutations of the transcription factor FOXL2 in BPES patients<ref type="note" target="#fn1"></ref></title><author><name sortKey="Nallathambi, Jeyabalan" sort="Nallathambi, Jeyabalan" uniqKey="Nallathambi J" first="Jeyabalan" last="Nallathambi">Jeyabalan Nallathambi</name><affiliation wicri:level="1"><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Genetics, Dr. G.Venkataswamy Eye Research Institute, Aravind Medical Research Foundation, Aravind Eye Hospital</wicri:regionArea><wicri:noRegion>Aravind Eye Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Laissue, Paul" sort="Laissue, Paul" uniqKey="Laissue P" first="Paul" last="Laissue">Paul Laissue</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>INSERM U567, Team21, Genetics and Development Department, Institut Cochin, 24 rue du Faubourg St‐Jacques, 75014, Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>CNRS UMR8104, Institut Cochin, 24 rue du Faubourg St‐Jacques, 75014, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName></affiliation><affiliation wicri:level="4"><country xml:lang="fr">France</country><wicri:regionArea>Université Paris Descartes, Faculté de Médecine Cochin‐Port‐Royal, 24 rue du Faubourg St‐Jacques, 75014, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName><orgName type="university">Université Paris-Descartes</orgName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Université Denis Diderot, Paris VII, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Batista, Frank" sort="Batista, Frank" uniqKey="Batista F" first="Frank" last="Batista">Frank Batista</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>INSERM U567, Team21, Genetics and Development Department, Institut Cochin, 24 rue du Faubourg St‐Jacques, 75014, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>CNRS UMR8104, Institut Cochin, 24 rue du Faubourg St‐Jacques, 75014, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName></affiliation><affiliation wicri:level="4"><country xml:lang="fr">France</country><wicri:regionArea>Université Paris Descartes, Faculté de Médecine Cochin‐Port‐Royal, 24 rue du Faubourg St‐Jacques, 75014, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName><orgName type="university">Université Paris-Descartes</orgName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Université Denis Diderot, Paris VII, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Benayoun, Berenice A" sort="Benayoun, Berenice A" uniqKey="Benayoun B" first="Bérénice A." last="Benayoun">Bérénice A. Benayoun</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>INSERM U567, Team21, Genetics and Development Department, Institut Cochin, 24 rue du Faubourg St‐Jacques, 75014, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>CNRS UMR8104, Institut Cochin, 24 rue du Faubourg St‐Jacques, 75014, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName></affiliation><affiliation wicri:level="4"><country xml:lang="fr">France</country><wicri:regionArea>Université Paris Descartes, Faculté de Médecine Cochin‐Port‐Royal, 24 rue du Faubourg St‐Jacques, 75014, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName><orgName type="university">Université Paris-Descartes</orgName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Université Denis Diderot, Paris VII, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Ecole Normale Supérieure, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Lesaffre, Corinne" sort="Lesaffre, Corinne" uniqKey="Lesaffre C" first="Corinne" last="Lesaffre">Corinne Lesaffre</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>INSERM U567, Team21, Genetics and Development Department, Institut Cochin, 24 rue du Faubourg St‐Jacques, 75014, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>CNRS UMR8104, Institut Cochin, 24 rue du Faubourg St‐Jacques, 75014, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName></affiliation><affiliation wicri:level="4"><country xml:lang="fr">France</country><wicri:regionArea>Université Paris Descartes, Faculté de Médecine Cochin‐Port‐Royal, 24 rue du Faubourg St‐Jacques, 75014, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName><orgName type="university">Université Paris-Descartes</orgName></affiliation></author><author><name sortKey="Moumne, Lara" sort="Moumne, Lara" uniqKey="Moumne L" first="Lara" last="Moumné">Lara Moumné</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>INSERM U567, Team21, Genetics and Development Department, Institut Cochin, 24 rue du Faubourg St‐Jacques, 75014, Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>CNRS UMR8104, Institut Cochin, 24 rue du Faubourg St‐Jacques, 75014, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName></affiliation><affiliation wicri:level="4"><country xml:lang="fr">France</country><wicri:regionArea>Université Paris Descartes, Faculté de Médecine Cochin‐Port‐Royal, 24 rue du Faubourg St‐Jacques, 75014, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName><orgName type="university">Université Paris-Descartes</orgName></affiliation></author><author><name sortKey="Pandaranayaka, Pj Eswari" sort="Pandaranayaka, Pj Eswari" uniqKey="Pandaranayaka P" first="Pj Eswari" last="Pandaranayaka">Pj Eswari Pandaranayaka</name><affiliation wicri:level="1"><country xml:lang="fr">Inde</country><wicri:regionArea>Centre of Excellence in Bioinformatics, School of Biotechnology, Madurai Kamaraj University</wicri:regionArea><wicri:noRegion>Madurai Kamaraj University</wicri:noRegion></affiliation></author><author><name sortKey="Usha, Kim" sort="Usha, Kim" uniqKey="Usha K" first="Kim" last="Usha">Kim Usha</name><affiliation wicri:level="1"><country xml:lang="fr">Inde</country><wicri:regionArea>Orbit Clinic, Aravind Eye Hospital</wicri:regionArea><wicri:noRegion>Aravind Eye Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Krishnaswamy, Sankaran" sort="Krishnaswamy, Sankaran" uniqKey="Krishnaswamy S" first="Sankaran" last="Krishnaswamy">Sankaran Krishnaswamy</name><affiliation wicri:level="1"><country xml:lang="fr">Inde</country><wicri:regionArea>Centre of Excellence in Bioinformatics, School of Biotechnology, Madurai Kamaraj University</wicri:regionArea><wicri:noRegion>Madurai Kamaraj University</wicri:noRegion></affiliation></author><author><name sortKey="Sundaresan, Periasamy" sort="Sundaresan, Periasamy" uniqKey="Sundaresan P" first="Periasamy" last="Sundaresan">Periasamy Sundaresan</name><affiliation wicri:level="1"><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Genetics, Dr. G.Venkataswamy Eye Research Institute, Aravind Medical Research Foundation, Aravind Eye Hospital</wicri:regionArea><wicri:noRegion>Aravind Eye Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Veitia, Reiner A" sort="Veitia, Reiner A" uniqKey="Veitia R" first="Reiner A." last="Veitia">Reiner A. Veitia</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>INSERM U567, Team21, Genetics and Development Department, Institut Cochin, 24 rue du Faubourg St‐Jacques, 75014, Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>CNRS UMR8104, Institut Cochin, 24 rue du Faubourg St‐Jacques, 75014, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName></affiliation><affiliation wicri:level="4"><country xml:lang="fr">France</country><wicri:regionArea>Université Paris Descartes, Faculté de Médecine Cochin‐Port‐Royal, 24 rue du Faubourg St‐Jacques, 75014, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName><orgName type="university">Université Paris-Descartes</orgName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Université Denis Diderot, Paris VII, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>INSERM U567, Team21, Genetics and Development Department, Institut Cochin, 24 rue du Faubourg St‐Jacques, 75014, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Human Mutation</title><title level="j" type="alt">HUMAN MUTATION</title><idno type="ISSN">1059-7794</idno><idno type="eISSN">1098-1004</idno><imprint><biblScope unit="vol">29</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="E123">E123</biblScope><biblScope unit="page" to="E131">E131</biblScope><biblScope unit="page-count">1</biblScope><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2008-08">2008-08</date></imprint><idno type="ISSN">1059-7794</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1059-7794</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Mutations of the transcription factor FOXL2, involved in cranio‐facial and ovarian development lead to the Blepharophimosis‐Ptosis‐Epicanthus Inversus Syndrome (BPES) in human. Here, we describe nine mutations in the open reading frame of FOXL2. Six of them are novel: c.292T>A (p.Trp98Arg), c.323T>C (p.Leu108Pro), c.650C>G (p.Ser217Cys) and three frameshifts. We have performed localization and functional studies for three of them. We have observed a strong cytoplasmic mislocalization induced by the missense mutation p.Leu108Pro located in the forkhead (FKH) domain of FOXL2. In line with this, transcriptional activity assays confirmed the loss‐of‐function induced by this variant. Interestingly, the novel mutation p.Ser217Cys, mapping between the FKH and the polyalanine domain of FOXL2 and producing a mild eyelid phenotype, led to normal localization and transactivation. We have also modeled the structure of the FKH domain to explore the potential structural impact of the mutations reported here and other previously reported ones. This analysis shows that mutants can be sorted into two classes: those that potentially alter protein‐protein interactions and those that might disrupt the interactions with DNA. Our findings reveal new insights into the molecular effects of FOXL2 mutations, especially those affecting the FKH binding domain. © 2008 Wiley‐Liss, Inc.</div></front></TEI><affiliations><list><country><li>France</li><li>Inde</li></country><region><li>Île-de-France</li></region><settlement><li>Paris</li></settlement><orgName><li>Université Paris-Descartes</li></orgName></list><tree><country name="Inde"><noRegion><name sortKey="Nallathambi, Jeyabalan" sort="Nallathambi, Jeyabalan" uniqKey="Nallathambi J" first="Jeyabalan" last="Nallathambi">Jeyabalan Nallathambi</name></noRegion><name sortKey="Krishnaswamy, Sankaran" sort="Krishnaswamy, Sankaran" uniqKey="Krishnaswamy S" first="Sankaran" last="Krishnaswamy">Sankaran Krishnaswamy</name><name sortKey="Pandaranayaka, Pj Eswari" sort="Pandaranayaka, Pj Eswari" uniqKey="Pandaranayaka P" first="Pj Eswari" last="Pandaranayaka">Pj Eswari Pandaranayaka</name><name sortKey="Sundaresan, Periasamy" sort="Sundaresan, Periasamy" uniqKey="Sundaresan P" first="Periasamy" last="Sundaresan">Periasamy Sundaresan</name><name sortKey="Usha, Kim" sort="Usha, Kim" uniqKey="Usha K" first="Kim" last="Usha">Kim Usha</name></country><country name="France"><region name="Île-de-France"><name sortKey="Laissue, Paul" sort="Laissue, Paul" uniqKey="Laissue P" first="Paul" last="Laissue">Paul Laissue</name></region><name sortKey="Batista, Frank" sort="Batista, Frank" uniqKey="Batista F" first="Frank" last="Batista">Frank Batista</name><name sortKey="Batista, Frank" sort="Batista, Frank" uniqKey="Batista F" first="Frank" last="Batista">Frank Batista</name><name sortKey="Batista, Frank" sort="Batista, Frank" uniqKey="Batista F" first="Frank" last="Batista">Frank Batista</name><name sortKey="Batista, Frank" sort="Batista, Frank" uniqKey="Batista F" first="Frank" last="Batista">Frank Batista</name><name sortKey="Benayoun, Berenice A" sort="Benayoun, Berenice A" uniqKey="Benayoun B" first="Bérénice A." last="Benayoun">Bérénice A. Benayoun</name><name sortKey="Benayoun, Berenice A" sort="Benayoun, Berenice A" uniqKey="Benayoun B" first="Bérénice A." last="Benayoun">Bérénice A. Benayoun</name><name sortKey="Benayoun, Berenice A" sort="Benayoun, Berenice A" uniqKey="Benayoun B" first="Bérénice A." last="Benayoun">Bérénice A. Benayoun</name><name sortKey="Benayoun, Berenice A" sort="Benayoun, Berenice A" uniqKey="Benayoun B" first="Bérénice A." last="Benayoun">Bérénice A. Benayoun</name><name sortKey="Benayoun, Berenice A" sort="Benayoun, Berenice A" uniqKey="Benayoun B" first="Bérénice A." last="Benayoun">Bérénice A. Benayoun</name><name sortKey="Laissue, Paul" sort="Laissue, Paul" uniqKey="Laissue P" first="Paul" last="Laissue">Paul Laissue</name><name sortKey="Laissue, Paul" sort="Laissue, Paul" uniqKey="Laissue P" first="Paul" last="Laissue">Paul Laissue</name><name sortKey="Laissue, Paul" sort="Laissue, Paul" uniqKey="Laissue P" first="Paul" last="Laissue">Paul Laissue</name><name sortKey="Lesaffre, Corinne" sort="Lesaffre, Corinne" uniqKey="Lesaffre C" first="Corinne" last="Lesaffre">Corinne Lesaffre</name><name sortKey="Lesaffre, Corinne" sort="Lesaffre, Corinne" uniqKey="Lesaffre C" first="Corinne" last="Lesaffre">Corinne Lesaffre</name><name sortKey="Lesaffre, Corinne" sort="Lesaffre, Corinne" uniqKey="Lesaffre C" first="Corinne" last="Lesaffre">Corinne Lesaffre</name><name sortKey="Moumne, Lara" sort="Moumne, Lara" uniqKey="Moumne L" first="Lara" last="Moumné">Lara Moumné</name><name sortKey="Moumne, Lara" sort="Moumne, Lara" uniqKey="Moumne L" first="Lara" last="Moumné">Lara Moumné</name><name sortKey="Moumne, Lara" sort="Moumne, Lara" uniqKey="Moumne L" first="Lara" last="Moumné">Lara Moumné</name><name sortKey="Veitia, Reiner A" sort="Veitia, Reiner A" uniqKey="Veitia R" first="Reiner A." last="Veitia">Reiner A. Veitia</name><name sortKey="Veitia, Reiner A" sort="Veitia, Reiner A" uniqKey="Veitia R" first="Reiner A." last="Veitia">Reiner A. Veitia</name><name sortKey="Veitia, Reiner A" sort="Veitia, Reiner A" uniqKey="Veitia R" first="Reiner A." last="Veitia">Reiner A. Veitia</name><name sortKey="Veitia, Reiner A" sort="Veitia, Reiner A" uniqKey="Veitia R" first="Reiner A." last="Veitia">Reiner A. Veitia</name><name sortKey="Veitia, Reiner A" sort="Veitia, Reiner A" uniqKey="Veitia R" first="Reiner A." last="Veitia">Reiner A. Veitia</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/France/Analysis
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000434 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/France/Analysis/biblio.hfd -nk 000434 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= France
|étape= Analysis
|type= RBID
|clé= ISTEX:13CCA258DAFD6CE074F7EB9382B0FED0A269F94E
|texte= Differential functional effects of novel mutations of the transcription factor FOXL2 in BPES patients
}}
| This area was generated with Dilib version V0.6.31. |  |